Article
Transcriptome sequencing of human breast cancer reveals aberrant intronic transcription in amplicons and dysregulation of alternative splicing with major therapeutic implications.
International journal of oncology - 1 Jan 2016
Forootan Shiva Seyed, Butler Joe M, Gardener Derek, Jones Dawn, Baird Alison E, Dodson Andrew, Darby Alistair, Kenny John, Hall Neil, Cossins Andrew R, Foster Christopher S, Gosden Christine M
Abstract excerpt
Advances in genomic and transcriptome sequencing are revealing the massive scale of previously unrecognised alterations occurring during neoplastic transformation. Breast cancers are genetically and phenotypically heterogeneous. Each of the three major subtypes [ERBB2 amplified, estrogen receptor (ESR)-positive and triple-negative] poses diagnostic and therapeutic challenges. Here we show, using high-resolution...
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