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Article

Conservation and coevolution determine evolvability of different classes of disordered residues in human intrinsically disordered proteins.

Proteins - 1 Mar 2022

Basu Sushmita, Bahadur Ranjit Prasad

Abstract excerpt

Structure, function, and evolution are interdependent properties of proteins. Diversity of protein functions arising from structural variations is a potential driving force behind protein evolvability. Intrinsically disordered proteins or regions (IDPs or IDRs) lack well-defined structure under normal physiological conditions, yet, they are highly functional. Increased occurrence of IDPs in eukaryotes compared to...

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PMID: 34626492
DOI: 10.1002/prot.26261

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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