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Article

Insulin Deficiency From Insulin Gene Mutation Leads to Smaller Pancreas.

Diabetes care - 1 Apr 2023

Wright Jordan J, Williams Jonathan M, Letourneau-Freiberg Lisa R, Kandasamy Balamurugan, Reyes Demetra, Kanegusuku Anastasia Gant, Philipson Louis, Greeley Siri Atma W, Hilmes Melissa A, Powers Alvin C, Virostko John, Moore Daniel J

Abstract excerpt

OBJECTIVE: To determine the mechanism of reduced pancreas size in type 1 diabetes and the significance of islet-derived insulin in pancreatic growth. RESEARCH DESIGN AND METHODS: Using a validated and standardized MRI protocol, we measured pancreas volume and shape in a family with an autosomal-dominant insulin gene mutation that results in insulin deficiency similar in severity to that of type 1 diabetes but...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36724370
DOI: 10.2337/dc22-2082
PMCID: PMC10090891

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