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Maintenance of β-Cell Maturity and Plasticity in the Adult Pancreas

14 May 2012

Abstract excerpt

Diabetes occurs when the pancreas fails to produce and secrete sufficient insulin for the maintenance of glucose homeostasis. Although many factors required for β-cell development have been elucidated, we know surprisingly little regarding the mechanisms that maintain the differentiated state of adult β-cells. Despite years of fruitful research, many hurdles remain before we can replace failing β-cells in...

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PMID: 22618775
DOI: 10.2337/db11-1361

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