Article

Intron retention as a novel source of cancer neoantigens

2018-04-27

Abstract excerpt

Personalized cancer vaccine strategies directed at tumor neoantigens derived from somatic mutations in the DNA are currently under prospective evaluation 1, 2 . Alterations in tumor RNA, rather than DNA, may also represent a previously-unexplored source of neoantigens. Here, we show that intron retention, a widespread feature of cancer transcriptomes 3, 4 , represents a novel source of tumor neoantigens. We deve...

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Literature Corpus work: bebc8fef-fdf3-537a-939e-517236655e45
DOI: 10.1101/309450

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