Article

The knockout of the HMG domain of the porcine SRY gene causes sex reversal in gene-edited pigs

2019-04-24

Abstract excerpt

1 The sex-determining region on the Y chromosome (SRY) is thought to be the central genetic element of male sex development. Mutations within the SRY gene are associated with a male-to-female sex reversal syndrome in humans and other mammalian species such as mice and rabbits. However, the underlying mechanisms are largely unknown. To understand the biological function of the SRY gene, a site-directed mutational a...

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Literature Corpus work: bebaf2c1-0537-5f55-b7ea-1f2c1d8e1904
DOI: 10.1101/617589

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