Article
Mutation of the Sp1 binding site in the 5' flanking region of SRY causes sex reversal in rabbits.
Oncotarget - 13 Jun 2017
Song Yuning, Liu Tingjun, Wang Yong, Deng Jichao, Chen Mao, Yuan Lin, Lu Yi, Xu Yuxin, Yao Haobin, Li Zhanjun, Lai Liangxue
Abstract excerpt
Sex-determining region Y is a crucial gene that initiates male sex determination in mammals. Mutations of the Sp1-binding site in the 5' flanking region of SRY are associated with clinical male-to-female sex reversal syndrome, although such occurrences are rare and, until now, have not been reported in animal models. In this study, we mutated Sp1-binding sites in the 5' flanking region of the rabbit SRY gene...
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