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CRISPR-Mediated SRY Gene Mutation Increases the Expression of Female Lineage-Specific Gene in Pre-Implantation Buffalo Embryo.

Reproduction in domestic animals = Zuchthygiene - 1 Nov 2024

Punetha Meeti, Saini Sheetal, Sharma Surabhi, Thakur Swati, Dahiya Priya, Mangal Manu, Kumar Rajesh, Kumar Dharmendra, Yadav P S

Abstract excerpt

In mammals, sex determination is governed by the SRY gene on the Y chromosome, redirecting gonadal development from forming ovaries to testes. Mutations or alterations in the SRY gene can significantly affect phenotypic changes and lineage-specific markers. This study aims to elucidate the role of the SRY gene in buffalo embryos using CRISPR-Cas9 technology. We designed a crRNA targeting the HMG domain of the SRY...

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PMID: 39498956
DOI: 10.1111/rda.14739

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CRISPR-Mediated SRY Gene Mutation Increases the Expression of Female Lineage-Specific Gene in Pre-Implantation Buffalo Embryo.PMID 39498956Read ↗

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