Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Knockout of the HMG domain of the porcine SRY gene causes sex reversal in gene-edited pigs.

Proceedings of the National Academy of Sciences of the United States of America - 12 Jan 2021

Kurtz Stefanie, Lucas-Hahn Andrea, Schlegelberger Brigitte, Göhring Gudrun, Niemann Heiner, Mettenleiter Thomas C, Petersen Björn

Abstract excerpt

The sex-determining region on the Y chromosome (SRY) is thought to be the central genetic element of male sex development in mammals. Pathogenic modifications within the SRY gene are associated with a male-to-female sex reversal syndrome in humans and other mammalian species, including rabbits and mice. However, the underlying mechanisms are largely unknown. To understand the biological function of the SRY gene,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disorders of Sex Development
Share to Frameshift Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, sry

Share to Proof of Concept Study

Share to Protein Domains

Share to Sex Determination Processes

Share to Sex-Determining Region Y Protein

Share to Y Chromosome

Source

Open in PubMed Open full text

Identifiers

PMID: 33443157
DOI: 10.1073/pnas.2008743118
PMCID: PMC7812820

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Knockout of the HMG domain of the porcine SRY gene causes sex reversal in gene-edited pigs.PMID 33443157Read ↗

The knockout of the HMG domain of the porcine SRY gene causes sex reversal in gene-edited pigsSemantic proximity Read ↗

Mutation of the Sp1 binding site in the 5' flanking region of SRY causes sex reversal in rabbits.Semantic proximity Read ↗

Generation and mutational analysis of a transgenic mouse model of human SRYSemantic proximity Read ↗

CRISPR-Mediated SRY Gene Mutation Increases the Expression of Female Lineage-Specific Gene in Pre-Implantation Buffalo Embryo.Semantic proximity Read ↗

CRISPR/Cas9-mediated mosaic mutation of SRY gene induces hermaphroditism in rabbits.Semantic proximity Read ↗

High mobility group A2 (HMGA2) deficiency in pigs leads to dwarfism, abnormal fetal resource allocation, and cryptorchidism.Semantic proximity Read ↗

Structure–function analysis of mouse Sry reveals dual essential roles of the C-terminal polyglutamine tract in sex determinationSemantic proximity Read ↗

Pregnancy in an SRY-Negative XX Developmental Sex Disorder Pig After Re-Moving an OvotestisSemantic proximity Read ↗

Generation of germline ablated male pigs by CRISPR/Cas9 editing of the NANOS2 geneSemantic proximity Read ↗

Efficient Generation of Gene-Modified Pigs Harboring Precise Orthologous Human Mutation via CRISPR/Cas9-Induced Homology-Directed Repair in Zygotes.Semantic proximity Read ↗

SEX IN THE 90s:<i>SRY</i>and the Switch to the Male PathwaySemantic proximity Read ↗

Somatic cell reprogramming-free generation of genetically modified pigs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.