Article
Somatic cell reprogramming-free generation of genetically modified pigs.
Science advances - 1 Sept 2016
Tanihara Fuminori, Takemoto Tatsuya, Kitagawa Eri, Rao Shengbin, Do Lanh Thi Kim, Onishi Akira, Yamashita Yukiko, Kosugi Chisato, Suzuki Hitomi, Sembon Shoichiro, Suzuki Shunichi, Nakai Michiko, Hashimoto Masakazu, Yasue Akihiro, Matsuhisa Munehide, Noji Sumihare, Fujimura Tatsuya, Fuchimoto Dai-Ichiro, Otoi Takeshige
Abstract excerpt
Genetically modified pigs for biomedical applications have been mainly generated using the somatic cell nuclear transfer technique; however, this approach requires complex micromanipulation techniques and sometimes increases the risks of both prenatal and postnatal death by faulty epigenetic reprogramming of a donor somatic cell nucleus. As a result, the production of genetically modified pigs has not been widely...
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