Article
High mobility group A2 (HMGA2) deficiency in pigs leads to dwarfism, abnormal fetal resource allocation, and cryptorchidism.
Proceedings of the National Academy of Sciences of the United States of America - 22 May 2018
Chung Jaewook, Zhang Xia, Collins Bruce, Sper Renan B, Gleason Katherine, Simpson Sean, Koh Sehwon, Sommer Jeffrey, Flowers William L, Petters Robert M, Piedrahita Jorge A
Abstract excerpt
Expression of HMGA2 is strongly associated with body size and growth in mice and humans. In mice, inactivation of one or both alleles of Hmga2 results in body-size reductions of 20% and 60%, respectively. In humans, microdeletions involving the HMGA2 locus result in short stature, suggesting the function of the HMGA2 protein is conserved among mammals. To test this hypothesis, we generated HMGA2-deficient pigs...
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