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The FusX TALE Base Editor (FusXTBE) for rapid mitochondrial DNA programming of human cells <i>in vitro</i> and zebrafish disease models <i>in vivo</i>

2021-05-20

Abstract excerpt

Functional analyses of mitochondria have been hampered by few effective approaches to manipulate mtDNA and a lack of existing animal models. Recently a TALE-derived base editor was shown to induce C-to-T (or G-to-A) sequence changes in mtDNA. We report here the FusX TALE Base Editor (FusXTBE) to facilitate broad-based access to TALE mitochondrial base editing technology. TALE Writer is a de novo in silico design...

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Identifiers and source

Literature Corpus work
d81334a9-d436-541a-ab81-afbf778ff93f
DOI
10.1101/2021.05.18.444740
Open publication

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The FusX TALE Base Editor (FusXTBE) for rapid mitochondrial DNA programming of human cells <i>in vitro</i> and zebrafish disease models <i>in vivo</i>DOI 10.1101/2021.05.18.444740
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