Development of the Mitochondrial Base Editor Analysis Package (MitoBEAP)

Abstract excerpt

For many years, the genetic manipulation of mitochondrial DNA was largely hampered by inefficient delivery of nucleic acids to mitochondria. However, the development of mitoCBEs, such as mitochondrial cytosine base editors (DdCBEs), which catalyse C•G-to-T•A conversions, and more recently, mitoABEs, such as transcription-activator-like effector (TALE)-linked deaminases (TALEDs) enabling A•T-to-G•C conversion, has...

Topics

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• Cytosine
• DNA, Mitochondrial
• Gene Editing
• Genome, Mitochondrial
• Leigh Disease
• Mitochondria
• Mutation
• Technology

Identifiers and source

Literature Corpus work

07fc8743-64a7-5978-891d-02f289f3b078

DOI

10.64898/2026.06.02.729539