Article

LKB1 and STRAD Promote Epithelial Ovarian Cancer Spheroid Cell Invasion

2024-09-10

Abstract excerpt

Late-stage epithelial ovarian cancer (EOC) involves widespread dissemination of malignant disease throughout the peritoneal cavity, often accompanied by ascites. EOC metastasis relies on the formation of multicellular aggregates, called spheroids. Given that Liver Kinase B1 (LKB1) is required for EOC spheroid viability and LKB1 loss in EOC cells decreases tumor burden in mice, we investigated whether the LKB1 comp...

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Literature Corpus work: 44d790fc-7a27-51b1-907f-4c96a0285f05
DOI: 10.20944/preprints202409.0763.v1

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