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Article

Cohesin without cohesion: a novel role for Pds5 in Saccharomyces cerevisiae.

PloS one - 1 Jan 2014

Tong Kevin, Skibbens Robert V

Abstract excerpt

High fidelity chromosome segregation during mitosis requires that cells identify the products of DNA replication during S-phase and then maintain that identity until anaphase onset. Sister chromatid identity is achieved through cohesin complexes (Smc1, Smc3, and Mcd1 and Irr1/Scc3), but the structure through which cohesins perform this task remains enigmatic. In the absence of unambiguous data, a popular model is...

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Share to Acetylation
Share to Cell Survival
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA, Fungal

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Source

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Identifiers

PMID: 24963665
DOI: 10.1371/journal.pone.0100470
PMCID: PMC4070927

Genes

WAPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cohesin without cohesion: a novel role for Pds5 in Saccharomyces cerevisiae.PMID 24963665Read ↗

Pds5p is an essential chromosomal protein required for both sister chromatid cohesion and condensation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Brca2, Pds5 and Wapl differentially control cohesin chromosome association and functionSemantic proximity Read ↗

Intersection between the regulators of sister chromatid cohesion establishment and maintenance in budding yeast indicates a multi-step mechanism.Semantic proximity Read ↗

Pds5p regulates the maintenance of sister chromatid cohesion and is sumoylated to promote the dissolution of cohesion.Semantic proximity Read ↗

Faithful anaphase is ensured by Mis4, a sister chromatid cohesion molecule required in S phase and not destroyed in G1 phase.Semantic proximity Read ↗

Pds5 regulates sister chromatid cohesion by controlling cohesin ATPase activity through the Eco1-Smc3 acetylation pathway.Semantic proximity Read ↗

Pds5 promotes cohesin acetylation and stable cohesin-chromosome interaction.Semantic proximity Read ↗

Pds5 promotes and protects cohesin acetylation.Semantic proximity Read ↗

Cell biology: cohesin ring exit gate revealed.Semantic proximity Read ↗

Postreplicative formation of cohesion is required for repair and induced by a single DNA break.Semantic proximity Read ↗

Budding yeast Wpl1(Rad61)-Pds5 complex counteracts sister chromatid cohesion-establishing reaction.Semantic proximity Read ↗

Cohesins: chromosomal proteins that prevent premature separation of sister chromatids.Semantic proximity Read ↗

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