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Article

Pds5 promotes cohesin acetylation and stable cohesin-chromosome interaction.

EMBO reports - 29 Jun 2012

Vaur Sabine, Feytout Amélie, Vazquez Stéphanie, Javerzat Jean-Paul

Abstract excerpt

Pds5 and Wpl1 act as anti-establishment factors preventing sister-chromatid cohesion until counteracted in S-phase by the cohesin acetyl-transferase Eso1. However, Pds5 is also required to maintain sister-chromatid cohesion in G2. Here, we show that Pds5 is essential for cohesin acetylation by Eso1 and ensures the maintenance of cohesion by promoting a stable cohesin interaction with replicated chromosomes. The...

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Share to Acetylation
Share to Chromatids
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22640989
DOI: 10.1038/embor.2012.72
PMCID: PMC3388792

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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