Article
Structure of the human cohesin inhibitor Wapl.
Proceedings of the National Academy of Sciences of the United States of America - 9 Jul 2013
Ouyang Zhuqing, Zheng Ge, Song Jianhua, Borek Dominika M, Otwinowski Zbyszek, Brautigam Chad A, Tomchick Diana R, Rankin Susannah, Yu Hongtao
Abstract excerpt
Cohesin, along with positive regulators, establishes sister-chromatid cohesion by forming a ring to circle chromatin. The wings apart-like protein (Wapl) is a key negative regulator of cohesin and forms a complex with precocious dissociation of sisters protein 5 (Pds5) to promote cohesin release from chromatin. Here we report the crystal structure and functional characterization of human Wapl. Wapl contains a...
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