StarSignDNA: Signature tracing for accurate representation of mutational processes

Abstract excerpt

All cell lineages accumulate mutations over time, increasing the probability that some lineages eventually become malignant. Many of the processes responsible for generating mutations are leaving a characteristic footprint in the genome that allows their presence to be detected. However, the mutational pattern in a tumor is usually the combined result of multiple mutational processes being at work simultaneously,...

Topics

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• Algorithms
• Amino Acid Substitution
• Carcinoma
• Cluster Analysis
• Epigenomics
• Genome
• Models, Statistical
• Models, Theoretical

Identifiers and source

Literature Corpus work

be884d58-9a21-56ba-9ecf-5101ade5c23a

DOI

10.1101/2024.06.29.601345