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Article

Learning mutational signatures and their multidimensional genomic properties with TensorSignatures.

Nature communications - 15 Jun 2021

Vöhringer Harald, Hoeck Arne Van, Cuppen Edwin, Gerstung Moritz

Abstract excerpt

We present TensorSignatures, an algorithm to learn mutational signatures jointly across different variant categories and their genomic localisation and properties. The analysis of 2778 primary and 3824 metastatic cancer genomes of the PCAWG consortium and the HMF cohort shows that all signatures operate dynamically in response to genomic states. The analysis pins differential spectra of UV mutagenesis found in...

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Identifiers

PMID: 34131135
DOI: 10.1038/s41467-021-23551-9
PMCID: PMC8206343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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