Article
A Simple Model-Based Approach to Inferring and Visualizing Cancer Mutation Signatures.
PLoS genetics - 1 Dec 2015
Shiraishi Yuichi, Tremmel Georg, Miyano Satoru, Stephens Matthew
Abstract excerpt
Recent advances in sequencing technologies have enabled the production of massive amounts of data on somatic mutations from cancer genomes. These data have led to the detection of characteristic patterns of somatic mutations or "mutation signatures" at an unprecedented resolution, with the potential for new insights into the causes and mechanisms of tumorigenesis. Here we present new methods for modelling,...
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