Article

Prion Protein Folding Mechanism Revealed by Pulling Force Studies

2020-03-09

Abstract excerpt

The mammalian prion protein (PrP) engages with the ribosome-Sec61 translocation channel complex to generate different topological variants that are either physiological, or involved in neurodegenerative diseases. Here, we describe cotranslational folding and translocation mechanisms of PrP coupled to a Xbp1-based arrest peptide (AP) as folding sensor, to measure forces acting on PrP nascent chain. Our data reveal...

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Literature Corpus work: be82a18c-25ee-5af6-a861-44ca74cec820
DOI: 10.1101/2020.03.09.983510

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