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Article

Mechanical resistance in unstructured proteins.

Biophysical journal - 18 Jun 2013

Jónsson Sigurður Ægir, Mitternacht Simon, Irbäck Anders

Abstract excerpt

Single-molecule pulling experiments on unstructured proteins linked to neurodegenerative diseases have measured rupture forces comparable to those for stable folded proteins. To investigate the structural mechanisms of this unexpected force resistance, we perform pulling simulations of the amyloid β-peptide (Aβ) and α-synuclein (αS), starting from simulated conformational ensembles for the free monomers. For both...

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Identifiers

PMID: 23790381
DOI: 10.1016/j.bpj.2013.05.003
PMCID: PMC3686333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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