Structural and mutational analysis of the ribosome-arresting human XBP1u

Abstract excerpt

XBP1u, a central component of the unfolded protein response (UPR), is a mammalian protein containing a functionally critical translational arrest peptide (AP). Here, we present a 3 Å cryo-EM structure of the stalled human XBP1u AP. It forms a unique turn in the upper part of the ribosomal exit tunnel and causes a subtle distortion of the peptidyl transferase center, explaining the temporary translational arrest in...

Topics

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• Cryoelectron Microscopy
• Eukaryotic Initiation Factor-2
• Eukaryotic Initiation Factors
• Molecular Docking Simulation
• Multiprotein Complexes
• Peptidase Inhibition and Analysis
• RNA and protein synthesis mechanisms
• RNA modifications and cancer

Identifiers and source

Literature Corpus work

0ce7f70c-dfee-58fd-be0e-ad5a976f0006

DOI

10.1101/588681