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Article

Combinatorial control of prion protein biogenesis by the signal sequence and transmembrane domain.

The Journal of biological chemistry - 13 Jul 2001

Kim S J, Rahbar R, Hegde R S

Abstract excerpt

The prion protein (PrP) is synthesized in three topologic forms at the endoplasmic reticulum. (sec)PrP is fully translocated into the endoplasmic reticulum lumen, whereas (Ntm)PrP and (Ctm)PrP are single-spanning membrane proteins of opposite orientation. Increased generation of (Ctm)PrP in either transgenic mice or humans is associated with the development of neurodegenerative disease. To study the mechanisms by...

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Identifiers

PMID: 11359769
DOI: 10.1074/jbc.M101638200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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