Article
Cotranslational partitioning of nascent prion protein into multiple populations at the translocation channel.
Molecular biology of the cell - 1 Nov 2002
Kim Soo Jung, Hegde Ramanujan S
Abstract excerpt
The decisive events that direct a single polypeptide such as the prion protein (PrP) to be synthesized at the endoplasmic reticulum in both fully translocated and transmembrane forms are poorly understood. In this study, we demonstrate that the topological heterogeneity of PrP is determined cotranslationally, while at the translocation channel. By evaluating sequential intermediates during PrP topogenesis, we...
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