Article

Probing interplays between human XBP1u translational arrest peptide and 80S ribosome

2021-06-22

Abstract excerpt

The ribosome stalling mechanism is a crucial biological process; yet its atomistic underpinning is still elusive. In this framework, the XBP1u translational arrest peptide (AP) plays a central role in regulating the Unfolded Protein Response (UPR) in eukaryotic cells. Here, we report multi-microseconds all atom molecular dynamics simulations designed to probe the interactions between the XBP1u AP and the mammalian...

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Literature Corpus work: 2c868bd1-b0c8-54e8-9dba-09ba96c53aa1
DOI: 10.1101/2021.06.22.449432

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