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Article

Rapid folding of the prion protein captured by pressure-jump.

European biophysics journal : EBJ - 1 Jun 2009

Jenkins David C, Pearson David S, Harvey Andrew, Sylvester Ian D, Geeves Michael A, Pinheiro Teresa J T

Abstract excerpt

The conversion of the cellular form of the prion protein (PrP(C)) to an altered disease state, generally denoted as scrapie isoform (PrP(Sc)), appears to be a crucial molecular event in prion diseases. The details of this conformational transition are not fully understood, but it is perceived that they are associated with misfolding of PrP or its incapacity to maintain the native fold during its cell cycle. Here...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19255752
DOI: 10.1007/s00249-009-0420-6
PMCID: PMC4509520

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