Article

Multi-Transcriptomic Analysis Points to Early Organelle Dysfunction in Human Astrocytes in Alzheimer’s Disease

2021-06-25

Abstract excerpt

<title>Abstract</title> <p>BackgroundRecent gene profiling of human AD astrocytes using single-nucleus RNA sequencing is limited by the low number of differentially expressed genes detected, and the small size of cohorts. We improved on prior studies with a novel systems-biology-based approach that can be used with available data from large cohorts.Methods Brain-cell specific gene clusters were generated from RNA...

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Literature Corpus work: e3c3105c-2622-5eca-b1bf-43897885098c
DOI: 10.21203/rs.3.rs-426597/v2

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