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Multi-transcriptomic analysis points to early organelle dysfunction in human astrocytes in Alzheimer's disease

7 Feb 2022

Abstract excerpt

The phenotypic transformation of astrocytes in Alzheimer's disease (AD) is still not well understood. Recent analyses based on single-nucleus RNA sequencing of postmortem Alzheimer's disease (AD) samples are limited by the low number of sequenced astrocytes, small cohort sizes, and low number of differentially expressed genes detected. To optimize the detection of astrocytic genes, we employed a novel strategy...

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PMID: 35143967
DOI: 10.1016/j.nbd.2022.105655

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