Article

Population-level comparisons of gene regulatory networks modeled on high-throughput single-cell transcriptomics data

2023-01-20

Abstract excerpt

Single-cell technologies enable high-resolution studies of phenotype-defining molecular mechanisms. However, data sparsity and cellular heterogeneity make modeling biological variability across single-cell samples difficult. We present SCORPION , a tool that uses a message-passing algorithm to reconstruct comparable gene regulatory networks from single cell/nuclei RNA-seq data that are suitable for population-lev...

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Literature Corpus work: acc99e0c-b159-513a-b18a-ef1c3595dece
DOI: 10.1101/2023.01.20.524974

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