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Article

Structure of prothrombin in the closed form reveals new details on the mechanism of activation.

Scientific reports - 13 Feb 2018

Chinnaraj Mathivanan, Chen Zhiwei, Pelc Leslie A, Grese Zachary, Bystranowska Dominika, Di Cera Enrico, Pozzi Nicola

Abstract excerpt

The clotting factor prothrombin exists in equilibrium between closed and open conformations, but the physiological role of these forms remains unclear. As for other allosteric proteins, elucidation of the linkage between molecular transitions and function is facilitated by reagents stabilized in each of the alternative conformations. The open form of prothrombin has been characterized structurally, but little is...

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Identifiers

PMID: 29440720
DOI: 10.1038/s41598-018-21304-1
PMCID: PMC5811608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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