Article
Gain-of-Function Variant p.Pro2555Arg of von Willebrand Factor Increases Aggregate Size through Altering Stem Dynamics.
Thrombosis and haemostasis - 1 Feb 2022
Huck Volker, Chen Po-Chia, Xu Emma-Ruoqi, Tischer Alexander, Klemm Ulrike, Aponte-Santamaría Camilo, Mess Christian, Obser Tobias, Kutzki Fabian, König Gesa, Denis Cécile V, Gräter Frauke, Wilmanns Matthias, Auton Matthew, Schneider Stefan W, Schneppenheim Reinhard, Hennig Janosch, Brehm Maria A
Abstract excerpt
The multimeric plasma glycoprotein (GP) von Willebrand factor (VWF) is best known for recruiting platelets to sites of injury during primary hemostasis. Generally, mutations in the VWF gene lead to loss of hemostatic activity and thus the bleeding disorder von Willebrand disease. By employing cone and platelet aggregometry and microfluidic assays, we uncovered a platelet GPIIb/IIIa-dependent prothrombotic gain of...
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