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Article

Dissecting the contribution of thrombin exosite I in the recognition of thrombin binding aptamer.

The FEBS journal - 1 Dec 2013

Pica Andrea, Russo Krauss Irene, Merlino Antonello, Nagatoishi Satoru, Sugimoto Naoki, Sica Filomena

Abstract excerpt

Thrombin plays a pivotal role in the coagulation cascade; therefore, it represents a primary target in the treatment of several blood diseases. The 15-mer DNA oligonucleotide 5'-GGTTGGTGTGGTTGG-3', known as thrombin binding aptamer (TBA), is a highly potent inhibitor of the enzyme. TBA folds as an antiparallel chair-like G-quadruplex structure, with two G-tetrads surrounded by two TT loops on one side and a TGT...

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Identifiers

PMID: 24128303
DOI: 10.1111/febs.12561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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