An RNA aptamer exploits exosite-dependent allostery to achieve specific inhibition of coagulation factor IXa

Abstract excerpt

Hemostasis relies on a reaction network of serine proteases and their cofactors to form a blood clot. Coagulation factor IXa (protease) plays an essential role in hemostasis as evident from the bleeding disease associated with its absence. RNA aptamers specifically targeting individual coagulation factors have potential as anticoagulants and as probes of the relationship between structure and function. Here, we...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Blood Coagulation and Thrombosis Mechanisms
• Share to Cell Adhesion Molecules Research
• Share to Hemophilia Treatment and Research