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Article

Functional Characterization of Antithrombin Mutations by Monitoring of Thrombin Inhibition Kinetics.

International journal of molecular sciences - 20 Feb 2021

Reda Sara, Müller Jens, Pavlova Anna, Pezeshkpoor Behnaz, Oldenburg Johannes, Pötzsch Bernd, Rühl Heiko

Abstract excerpt

Inactivation of thrombin by the endogenous inhibitor antithrombin (AT) is a central mechanism in the regulation of hemostasis. This makes hereditary AT deficiency, which is caused by SERPINC1 gene mutations, a major thrombophilic risk factor. Aim of this study was to assess to what extent AT mutations impair thrombin inhibition kinetics. The study population included 36 thrombophilic patients with 19 different...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Animals
Antithrombins
Cattle
Child
Child, Preschool
Female
Half-Life
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kinetics

Middle Aged

Mutation

Thrombin

Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 33672736
DOI: 10.3390/ijms22042119
PMCID: PMC7924598

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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