Article

From 1D sequence to 3D chromatin dynamics and cellular functions: a phase separation perspective

2018-01-28

Abstract excerpt

The high-order chromatin structure plays a non-negligible role in gene regulation. However, the mechanism for the formation of different chromatin structures in different cells and the sequence dependence of this process remain to be elucidated. As the nucleotide distributions in human and mouse genomes are highly uneven, we identified CGI forest and prairie genomic domains based on CGI density, which better segre...

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Literature Corpus work: bdfe8aad-1334-5bb8-88d2-cf6d9fcd99d3
DOI: 10.1101/255174

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