Article
Characterization of a stable, metronidazole-resistant Clostridium difficile clinical isolate.
PloS one - 1 Jan 2013
Lynch Tarah, Chong Patrick, Zhang Jason, Hizon Romeo, Du Tim, Graham Morag R, Beniac Daniel R, Booth Timothy F, Kibsey Pamela, Miller Mark, Gravel Denise, Mulvey Michael R
Abstract excerpt
BACKGROUND: Clostridium difficile are gram-positive, spore forming anaerobic bacteria that are the leading cause of healthcare-associated diarrhea, usually associated with antibiotic usage. Metronidazole is currently the first-line treatment for mild to moderate C. difficile diarrhea however recurrence occurs at rates of 15-35%. There are few reports of C. difficile metronidazole resistance in the literature, and...
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