Article

Heme is crucial for medium-dependent metronidazole resistance in clinical isolates of <i>C. difficile</i>

2020-11-18

Abstract excerpt

Until recently, metronidazole was the first-line treatment for Clostridioides difficile infection and it is still commonly used. Though resistance has been reported due to the plasmid pCD-METRO, this does not explain all cases. Here, we investigate resistance to metronidazole in a collection of clinical isolates of C. difficile . We find that nearly all isolates demonstrate a heme-dependent increase in the minim...

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Literature Corpus work: 25cc1d93-c8a5-52a1-b140-702cdcedb653
DOI: 10.1101/2020.11.18.388959

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