Article

Plasmid-mediated metronidazole resistance in <i>Clostridioides difficile</i>

2019-05-29

Abstract excerpt

<h4>Background</h4> Metronidazole is used to treat mild- to moderate Clostridioides difficile infections (CDI). No clear mechanism for metronidazole resistance has been described for C. difficile . A patient treated in the Leiden University Medical Center suffered from recurrent CDI caused by a PCR ribotype (RT) 020 strain which developed resistance to metronidazole (MIC = 8 mg/L). Resistance is also seen in an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0154e3d0-b53a-5892-bf8c-3596f8ed241c
DOI: 10.1101/643775

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Plasmid-mediated metronidazole resistance in <i>Clostridioides difficile</i>DOI 10.1101/643775Read

Plasmid-mediated metronidazole resistance in Clostridioides difficile.Semantic proximity Read

Heme is crucial for medium-dependent metronidazole resistance in clinical isolates of <i>C. difficile</i>Semantic proximity Read

Genomic Study of a Clostridium difficile Multidrug Resistant Outbreak-Related Clone Reveals Novel Determinants of ResistanceSemantic proximity Read

Vancomycin resistance in <i>Enterococcus faecium</i> from the Dallas, Texas area is conferred predominantly on pRUM-like plasmidsSemantic proximity Read

Haem is crucial for medium-dependent metronidazole resistance in clinical isolates of Clostridioides difficileSemantic proximity Read

Detection of Plasmid-Mediated Resistance to Metronidazole in Clostridioides difficile from River WaterSemantic proximity Read

Genetic determinants of resistance to antimicrobial therapeutics are rare in publicly available Clostridioides difficile genome sequences.Semantic proximity Read

Clostridioides difficile as a Dynamic Vehicle for the Dissemination of Antimicrobial-Resistance Determinants: Review and In Silico AnalysisSemantic proximity Read

Chromosomal Resistance to Metronidazole in <i>Clostridioides difficile</i> can be Mediated By Epistasis Between Iron Homeostasis and OxidoreductasesSemantic proximity Read

Dynamic changes in the plasmidome and resistome in the gastrointestinal tract of chickensSemantic proximity Read

Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant <i>Clostridioides difficile</i>Semantic proximity Read

Plasmidome AMR screening (PAMRS) workflow: a rapid screening workflow for phenotypic characterization of antibiotic resistance in plasmidomesSemantic proximity Read