Article

Fluoroquinolone-Specific Resistance Trajectories in <i>E. coli</i> and their Dependence on the SOS-Response

2024-06-06

Abstract excerpt

Fluoroquinolones are essential for treating bacterial infections in both human and veterinary medicine. This study investigates the mechanisms behind acquired resistance to fluoroquinolones with a specific focus on the SOS response - a critical cellular pathway activated by DNA damage. Utilizing an experimental evolution approach, we exposed Escherichia coli to four fluoroquinolones and monitored the adaptation p...

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Literature Corpus work: a9aafef8-d107-5c54-80b9-f7ae54f2f3a4
DOI: 10.1101/2024.06.06.597756

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