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Biology of <i>Clostridium difficile</i>: Implications for Epidemiology and Diagnosis

27 Sept 2010

Abstract excerpt

Clostridium difficile is an anaerobic, spore-forming, gram-positive rod that causes a spectrum of antibiotic-associated colitis through the elaboration of two large clostridial toxins and other virulence factors. Since its discovery in 1978 as the agent responsible for pseudomembranous colitis, the organism has continued to evolve into an adaptable, aggressive, hypervirulent strain. Advances in molecular methods...

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PMID: 21682645
DOI: 10.1146/annurev-micro-090110-102824

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