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The landscape of intrinsic and evolved fluoroquinolone resistance in <i>Acinetobacter baumannii</i> includes suppression of drug-induced prophage replication

2018-10-14

Abstract excerpt

The emergence of fluoroquinolone resistance in nosocomial pathogens has restricted the clinical efficacy of this antibiotic class. In Acinetobacter baumannii , the majority of clinical isolates now show high-level resistance due to mutations in gyrA (DNA gyrase) and parC (Topo IV). To investigate the molecular basis for fluoroquinolone resistance, an exhaustive mutation analysis was performed in both drug sensi...

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Literature Corpus work
3529e404-eaca-52bf-aa89-3ea2953fd76a
DOI
10.1101/442681
Open publication

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