Article

Triglyceride Polygenic Score Identifies Differential Bleeding and Cardiovascular Risk with Aspirin in Primary Prevention

2026-02-25

Abstract excerpt

<h4>Aims</h4> Low-dose aspirin is no longer routinely recommended for primary prevention in older adults because bleeding risks outweigh cardiovascular benefits. We aimed to investigate whether polygenic scores (PGSs) could modify the effects of aspirin on major bleeding and major adverse cardiovascular events (MACE) in a trial of older individuals. <h4>Methods</h4> We conducted post-hoc genetic analysis of the...

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Literature Corpus work: bdd69d10-b0f7-529f-8d1d-f8d192190b70
DOI: 10.64898/2026.02.19.26346656

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