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Article

Associations of Blood Lipid-Related Polygenic Scores, Lifestyle Factors and Their Combined Effects with Risk of Coronary Artery Disease in the UK Biobank Cohort.

Journal of cardiovascular translational research - 1 Apr 2025

Choi Jungyoon, Wen Wanqing, Jia Guochong, Tao Ran, Long Jirong, Shu Xiao-Ou, Zheng Wei

Abstract excerpt

Circulating lipids play a crucial role in the development of coronary artery disease (CAD). However, it is unclear whether the genetic susceptibility to hyperlipidemia may interact with lifestyle factors in CAD risk. Using UK Biobank data from 328,606 participants, we evaluated combined effects of genetic susceptibility to hyperlipidemia and lifestyle factors with risk of CAD. We found that both blood...

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PMID: 39680354
DOI: 10.1007/s12265-024-10578-8

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CAD

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