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Article

Polygenic risk, aspirin, and primary prevention of coronary artery disease.

European heart journal. Cardiovascular pharmacotherapy - 8 Feb 2025

Yu Chenglong, Natarajan Pradeep, Patel Aniruddh P, Bhatia Harpreet S, Khera Amit V, Neumann Johannes T, Tsimikas Sotirios, Wolfe Rory, Nicholls Stephen J, Reid Christopher M, Zoungas Sophia, Tonkin Andrew M, McNeil John J, Lacaze Paul

Abstract excerpt

AIMS: Recent aspirin primary prevention trials failed to identify a net benefit of aspirin for preventing cardiovascular disease vs. the harms of bleeding. This study aimed to investigate whether a high-risk subgroup, individuals with elevated genetic predisposition to coronary artery disease (CAD), might derive more benefit than harm with aspirin, compared to those with lower genetic risk. METHODS AND RESULTS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39455425
DOI: 10.1093/ehjcvp/pvae085
PMCID: PMC11805692

Genes

CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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