Aspirin and the Risk of Colorectal Cancer According to Genetic Susceptibility among Older Individuals.

doi:10.1158/1940-6207.CAPR-22-0011

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Aspirin and the Risk of Colorectal Cancer According to Genetic Susceptibility among Older Individuals.

Cancer prevention research (Philadelphia, Pa.) - 5 Jul 2022

Bakshi Andrew, Cao Yin, Orchard Suzanne G, Carr Prudence R, Joshi Amit D, Manning Alisa K, Buchanan Daniel D, Umar Asad, Winship Ingrid M, Gibbs Peter, Zalcberg John R, Macrae Finlay, McNeil John J, Lacaze Paul, Chan Andrew T

Abstract excerpt

Although aspirin has been considered a promising agent for prevention of colorectal cancer, recent data suggest a lack of benefit among older individuals. Whether some individuals with higher risk of colorectal cancer may benefit from aspirin remains unknown. We used a 95-variant colorectal cancer polygenic risk score (PRS) to explore the association between genetic susceptibility to colorectal cancer and aspirin...

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PMID: 35348611
DOI: 10.1158/1940-6207.CAPR-22-0011
PMCID: PMC9256779

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