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Article

Genetic Variation in PEAR1, Cardiovascular Outcomes and Effects of Aspirin in a Healthy Elderly Population.

Clinical pharmacology and therapeutics - 1 Dec 2020

Lewis Joshua P, Riaz Moeen, Xie Sophia, Polekhina Galina, Wolfe Rory, Nelson Mark, Tonkin Andrew M, Reid Christopher M, Murray Anne M, McNeil John J, Shuldiner Alan R, Lacaze Paul

Abstract excerpt

The platelet endothelial aggregation receptor-1 (PEAR1) rs12041331 variant has been identified as a genetic determinant of platelet aggregation in response to antiplatelet therapies, including aspirin. However, association with atherothrombotic cardiovascular events is less clear, with limited evidence from large trials. Here, we tested association of rs12041331 with cardiovascular events and aspirin use in a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32562573
DOI: 10.1002/cpt.1959
PMCID: PMC7959328

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Genetic Variation in PEAR1, Cardiovascular Outcomes and Effects of Aspirin in a Healthy Elderly Population.PMID 32562573Read ↗

Genetic variation in PEAR1 is associated with platelet aggregation and cardiovascular outcomes.Semantic proximity Read ↗

Prospective Evaluation of Genetic Variation in Platelet Endothelial Aggregation Receptor 1 Reveals Aspirin-Dependent Effects on Platelet Aggregation Pathways.Semantic proximity Read ↗

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PEAR1 is not a major susceptibility gene for cardiovascular disease in a Flemish population.Semantic proximity Read ↗

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Triglyceride Polygenic Score Identifies Differential Bleeding and Cardiovascular Risk with Aspirin in Primary PreventionSemantic proximity Read ↗

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Targeted deep resequencing identifies coding variants in the PEAR1 gene that play a role in platelet aggregation.Semantic proximity Read ↗

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