Article

Prognostic and Therapeutic Implications of <i>BRAF</i> Mutations in Acute Myeloid Leukemia

2025-10-15

Abstract excerpt

Mutations in the RAS/MAPK signaling pathway are recurrent in acute myeloid leukemia (AML), primarily involving NRAS and KRAS . In contrast, mutations in the gene encoding an effector protein, BRAF, occur at relatively lower frequencies in AML and are associated with poor outcomes. To date, no comprehensive analysis has assessed the clinical and molecular characteristics of BRAF- mutated AML. In this study, we r...

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Literature Corpus work: bdbfbdac-05e3-566c-8e90-ec33c1968b90
DOI: 10.1101/2025.10.14.682328

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