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Article

Clinical implications of RAS mutations in AML: prognostic significance is based upon the involved gene and mutation complexity.

Blood advances - 14 Jul 2026

Colgan John N, Peplinski Jack H, Wang Yi-Cheng, Kirkey Danielle C, Wallace Logan K, Feng Yuan, Fan Li, Connerty Patrick, Ries Rhonda E, Lamble Adam, Huang Benjamin J, Alonzo Todd A, Ma Xiaotu, Tarlock Katherine, Meshinchi Soheil

Abstract excerpt

ABSTRACT: Acute myeloid leukemia (AML) is a heterogeneous disease with complex mutational profiles that lead to variable clinical outcomes. NRAS and KRAS are among the most frequently mutated genes in AML, but their clinical impact has not been well characterized. In this cohort of >2000 children and young adults with AML, we evaluated the role of mutations in RAS genes and mutation complexity in outcome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42118855
DOI: 10.1182/bloodadvances.2025018699
PMCID: PMC13352172

Genes

KMT2A
KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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