Article

Multiomic characterization, early detection, and therapeutic targeting of myeloid sarcoma

2025-12-05

Abstract excerpt

Myeloid sarcoma, an aggressive extramedullary subtype of acute myeloid leukemia (AML), occurs in ∼10% of patients, and has not yet been included in large-scale genomic studies. The critical biological changes that drive tumor evolution are unknown, its detection in asymptomatic patients remains a clinical challenge, and treatment options are limited as patients are often excluded from clinical trials, rendering it...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: db4e09ae-5414-5dce-bfc2-d964e62eef12
DOI: 10.64898/2025.12.04.689069

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multiomic characterization, early detection, and therapeutic targeting of myeloid sarcomaDOI 10.64898/2025.12.04.689069Read

Detection of prognostically relevant mutations and translocations in myeloid sarcoma by next generation sequencingSemantic proximity Read

Molecular Discordance between Myeloid Sarcomas and Concurrent Bone Marrows Occurs in Actionable Genes and Is Associated with Worse Overall Survival.Semantic proximity Read

Genomic, transcriptomic, and immunogenomic landscape of over 1300 sarcomas of diverse histology subtypesSemantic proximity Read

Next-generation sequencing reveals clinically actionable molecular markers in myeloid sarcomaSemantic proximity Read

Genomics of Acute Myeloid Leukemia Diagnosis and Pathways.Semantic proximity Read

Genomic analysis in myeloid sarcoma and comparison with paired acute myeloid leukemia.Semantic proximity Read

Extramedullary Acute Myeloid Leukemia in the De Novo Setting: Clinicopathologic Characteristics, Molecular Analysis, and Treatment OutcomesSemantic proximity Read

Dissecting the Genetic and Non-Genetic Heterogeneity of Acute Myeloid Leukemia Using Next-Generation Sequencing and In Vivo ModelsSemantic proximity Read

Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas.Semantic proximity Read

Myeloid sarcoma: An overview.Semantic proximity Read

Prognostic and Therapeutic Implications of <i>BRAF</i> Mutations in Acute Myeloid LeukemiaSemantic proximity Read

Genomic and immunogenomic profiling of extramedullary acute myeloid leukemia reveals actionable clonal branching and frequent immune editingSemantic proximity Read